বুধবার, ২০ ফেব্রুয়ারি, ২০১৩

Votto on verge of joining Canada for WBC

There were positive signals Tuesday night that Cincinnati Reds superstar Joey Votto would be added to Canada's roster for the World Baseball Classic ahead of Wednesday's deadline.

The first baseman from Toronto wants to play in the tournament, but the left knee he had surgery on last summer has cast some doubt on that.

To create some comfort on the part of the Reds, who signed him to a $225 million extension before last season, one possibility is that Votto joins the Canadian squad later to give Cincinnati more time to monitor his progress.

At the Classic, Votto could also ease his workload by splitting duties between first base and designated hitter with Justin Morneau.

Meanwhile, the Canadian squad did make one roster change Tuesday, naming left-handed Philadelphia Phillies prospect Jay Johnson of Sussex Corner, N.B., to the team in place of right-handed Milwaukee Brewers farmhand Nick Bucci, who withdrew after suffering a shoulder problem during a side session.

Johnson joins Mark Hardy of Campbell River, B.C., as the club?s only left-handers out of the bullpen (southpaw Andrew Albers of North Battleford, Sask., of the Minnesota Twins system will start), an issue director of national teams Greg Hamilton sought to address.

?We needed some options out of the bullpen and we believe Jay is a guy who gives us a chance to legitimately counter a good left-handed hitter in a key situation,? he said Tuesday morning. ?That?s what we?re looking at. He?s got the ability to punch out a left-hander in a tough spot and certainly has the stuff ? he?s not a whole lot of fun to see from the left side.?

Meanwhile, Pittsburgh Pirates catcher Russell Martin of Chelsea, Que., told Jon Paul Morosi of foxsports.com Monday that at the Classic he ?feels like playing shortstop. It?s a selfish move from my part. But it?s what I love to do. Sometimes you?ve got to do what you feel like doing for yourself. And I want to do it.?

While Martin has been taking ground balls with the Pirates, exactly how much shortstop he?ll actually play for Canada isn?t certain. Toronto-born Cale Iorg of the Detroit Tigers organization was slated to handle duties there.

?We respect Russ, we respect the thought process he has right now, and obviously we want him as part of our ball club and obviously we want him behind the plate,? said Hamilton. ?We will also discuss and work with him along his desire to see a little bit of time in the middle. What that means, we?re going to have to discuss as we move along here.?

Shi Davidi is the MLB Insider for sportsnet.ca. Come back to read his insight and opinion regularly.

Source: http://www.sportsnet.ca/baseball/2013/02/19/joey_votto_status_world_baseball_classic_canada/?utm_source=Home%20lineup%20RSS&utm_medium=feed&utm_content=Votto%20on%20verge%20of%20joining%20Canada%20for%20WBC%20

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A Brief History of the Lightbulb

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Source: http://www.popularmechanics.com/technology/gadgets/a-brief-history-of-the-lightbulb?src=rss

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মঙ্গলবার, ১৯ ফেব্রুয়ারি, ২০১৩

'Snooze button' on biological clocks improves cell adaptability

Monday, February 18, 2013

The circadian clocks that control and influence dozens of basic biological processes have an unexpected "snooze button" that helps cells adapt to changes in their environment.

A study by Vanderbilt University researchers published online Feb. 17 by the journal Natureprovides compelling new evidence that at least some species can alter the way that their biological clocks function by using different "synonyms" that exist in the genetic code.

"This provides organisms with a novel and previously unappreciated mechanism for responding to changes in their environment," said Professor of Biological Sciences Carl Johnson. He and Associate Professor of Biological Sciences Antonis Rokas collaborated on the study.

Like many written languages, the genetic code is filled with synonyms: differently spelled "words" that have the same or very similar meanings. For a long time, biologists thought that these synonyms, called synonymous codons, were in fact interchangeable. Recently, they have realized that this is not the case and that differences in synonymous codon usage have a significant impact on cellular processes, so scientists have advanced a wide variety of ideas about the role that these variations play.

The new insight is not only an important advance in understanding evolution at the molecular level, but it also has potential applications in biotechnology, such as biofuel production, and gene therapy.

"While biological clocks are vital to maintaining healthy patterns of sleep, metabolism, physiology and behavior, under certain environmental conditions strict adherence to these rhythms can be disadvantageous," said Michael Sesma of the National Institute of General Medical Sciences, which partially funded the work. "This work shows how organisms can ignore the clock under certain circumstances?much like hitting a biological snooze button on the internal timepiece?and enhance their survival in the face of ever-changing circumstances."

The basic letters of the genetic code are a quartet of molecules (nucleic acids) designated A, C, G and U. These are combined into 61 triplets called codons, which are analogous to words. The codons provide the blueprints that the cell's protein-building machinery uses to generate amino acids, which are the basic building blocks that make all the proteins found in living organisms. However, cells only use 20 amino acids. That means a number of amino acids are produced by several different codons. For example, CCA, CCG and CCC are synonymous codons because they all encode for the same amino acid, proline.

It turns out that there is a reason for this redundancy. Some codons are faster and easier for cells to process and assemble into proteins than others. Recognition of this difference led to the concept of optimal codons and the hypothesis that natural selection should drive organisms ? particularly fast growing ones ? to use genes that use optimal codons to make critical proteins that need to be highly abundant or synthesized rapidly in cells.

The problem with this hypothesis was shown by Johnson and Rokas' study of the effect of changing codon usage on the simple biological clock found in single-celled cyanobacteria (blue-green algae) and a similar study of the more complex biological clock found in bread mold performed by a team led by Yi Liu that were published together.

"What the Liu team found was that optimizing all the codons used by the fungal biological clock knocked the clock out, which was totally unexpected! Those researchers concluded that clock proteins in the fungus are not properly assembled if they are synthesized too rapidly; it's as if the speed of one's writing affected our ability to read the text," Johnson summarized.

In the cyanobacteria, however, the researchers observed a different phenomenon. At Vanderbilt, Research Associate Professor Yao Xu optimized the codons in the cyanobacteria's biological clock. This did not shut the clock down in the algae, but it did have a more subtle, but potentially as profound effect: It significantly reduced cell survival at certain temperatures.

"Xu figured that the biological clock with optimized codons might work better at lower temperatures and it did," Johnson said. However the substitution also modified the biological clock so it ran with a longer, 30-hour period. When forced to operate in a 24-hour daily light/dark cycles, the bacteria with the optimized clock grew significantly slower than "wild-type" cells. "In cyanobacteria, it's as if writing speed changes the meaning," said Rokas.

The potential importance of changes in synonymous codon usage in adapting to environmental factors is magnified by the fact that they can influence the operation of biological clocks, which function as a key adaptation to daily environmental rhythms. Biological clocks control and influence dozens of different basic biological processes, including sleeping and feeding patterns, core body temperature, brain activity, hormone production and cell regeneration.

"It is now clear that variations in codon usage is a fundamental and underappreciated form of gene regulation," said Rokas.

Recognition of the importance of this process has a number of potential applications in biotechnology. For example, "it should be possible to improve the ability of algae to robustly express biofuel-producing proteins from other organisms by optimizing the codons that they use," Johnson said.

###

Vanderbilt University: http://www.exploration.vanderbilt.edu

Thanks to Vanderbilt University for this article.

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Source: http://www.labspaces.net/126864/_Snooze_button__on_biological_clocks_improves_cell_adaptability

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সোমবার, ১৮ ফেব্রুয়ারি, ২০১৩

Coming Soon: The Ultimate Beginner's Guide to Real Estate ...

In the coming days we'll be releasing our Ultimate Beginner's Guide to Real Estate Investing. This guide will help provide new investors with the basic information they need to get their real estate business off the ground.

Interested in getting your hands on it?

Let us know . . .

Small_bp-squareJoshua Dorkin, BiggerPockets
E-Mail: webmaster@biggerpockets.com
Telephone: 877-831-4704
Website: http://www.biggerpockets.com
Your real estate investing home online!

Source: http://www.biggerpockets.com/forums/25/topics/83469-coming-soon-the-ultimate-beginners-guide-to-real-estate-investing-from-biggerpockets

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Mophie Outride review: action-cam case for iPhone can't replace dedicated shooters

Mophie Outride review actioncam case for iPhone can't replace dedicated shooters

Over the years, Mophie has become synonymous with extending the iPhone's battery life. The outfit's range of battery-filled iPhone cases has garnered rave reviews across the industry, and even I religiously used one on an iPhone 3G. In more recent days, the company has cautiously expanded into a few new areas -- namely, building battery cases for non-Apple phones, and creating the contraption shown above. The Mophie Outride is an action-cam case that's designed to be strapped onto helmets, automobile hoods and any other place where your average X Games wannabe would look to capture extreme sports footage.

But, unlike the myriad rivals on the market today, the Outride doesn't actually include a camera. Instead, you're supposed to strap your iPhone 4 or 4S into it (an iPhone 5 model has yet to be announced), allowing the smartphone you already own to handle the bulk of the work. At first blush, it sounded like an ideal solution to me. After all, I'm generally in favor of convergence and consolidation, and as an avid traveler, having one less thing to carry (in this case, a dedicated camera) is a godsend. In practice, however, the Outride did little outside of convincing me that GoPro exists for a reason.

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Source: Mophie

Source: http://www.engadget.com/2013/02/17/mophie-outride-review-iphone-action-cam-case/

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London Fashion Week: Old guard proves talent

IF THE first day of London Fashion Week was all about showcasing emerging talent, yesterday saw the old guard proving that they?ve very much still got it.

On Friday night, graduates of Central Saint Martin?s MA course showed their collections at one of the most anticipated shows of the week. Alumni Christopher Kane and Roksanda Ilinic sat in the front row looking for the fashion stars of tomorrow, and the collections were as avant garde and utterly unwearable as we?ve come to expect from students of what is arguably the best fashion course in the world.

Yesterday, however, London Fashion Week stalwarts including Clements Ribeiro, Jasper Conran and John Rocha left the exposed nipples and S&M references to the kids. These are some of the more established labels on the circuit and, as such, day two of the fashion extravaganza ? which sees designers showcasing their autumn/winter 2013-14 collections ? was decidedly grown-up.

Bohemian-flavoured husband and wife Clements Ribeiro went for a sophisticated urban punk aesthetic. Collars were heavy with jewels, shoes were flat, metallic and pointed of toe. Models wore mini kilts or tartan shift dresses, while delicate pieces came with chunky buckles.

John Rocha ? whose celebrated daughter Simone will show her own collection on Tuesday ? went for a slightly punky take on a buttoned-up aesthetic. Each model had a mass of black tulle in her hair like a gothic Miss Havisham. As ever, black featured heavily in his collection: it came in a simplified paisley pattern appliqu?d onto a delicate chiffon skirt; and on nippy little jackets with graphic cutouts on the collarbone.

However, a palette of mossy greens, sugary pinks and warm reds added interest. Skirts were full, silhouettes princessy and whimsical. Coats too ? whether a bell-shaped pink mohair number or a vivid green trench ? were full-skirted, enveloping the models without overwhelming them.

Jasper Conran is another member of British fashion?s old guard, but his collections remain fresh and new. Conran was inspired by Mia Farrow, and this was a swinging collection with a strong Sixties influence. Dresses and skirts were boxy and simple, worn with patent shoes with low block heels. The catwalk was a riot of colour ? bright orange, bubblegum pink, zingy violet ? and there was a touch of the Sixties air stewardess about the models.

Conran?s pieces were deceptively simple, with spliced seams revealing a hint of contrasting colour and paillettes tumbling effortlessly from a short shift dress. Possibly one of the most wearable collections to be shown so far, it was approachable but not staid, commercial yet eye-catching, and as accomplished as you?d expect for a designer who?s been on the circuit for decades.

Of the four fashion weeks around the world, London is considered the most avant garde, the young fashion rebel. However, it is increasingly proving its commercial credentials in an industry that?s worth ?21 billion to the UK economy.

This is the first London Fashion Week run by Natalie Massenet, the British Fashion Council?s new chairman. Launching the event on Friday, she said that at the recent New York Fashion Week there was ?palpable excitement? about what lay ahead in London.

London Fashion Week continues to grow in size and influence, and this season is one of the biggest to date, with 57 shows over five days. Over the past few years, a number of designers ? including Jonathan Saunders and Vivienne Westwood ? have returned to London after showing at other fashion weeks around the world. This week Welsh designer Julien Macdonald makes his return, while notable new additions to the schedule include L?Wren Scott and Tom Ford.

The latter ? one of the biggest names in fashion ? will stage his first full-scale womenswear show tomorrow. Also tomorrow, Motherwell-born Christopher Kane presents his collection: the most hotly anticipated show of the week. This will be Kane?s first show since signing a majority stake deal with luxury conglomerate PPR, the first British label to do so since Alexander McQueen in 2001.

This is also one of the most accessible London Fashion Weeks to date, with the British Fashion Council teaming up with YouTube for the first time to broadcast 21 shows live online. Online customers will be able to buy looks straight off the catwalk, watch the show live and follow it closely on Twitter.

This season also marks a heavier presence of high-street brands. Topshop has been involved in the event for years. For autumn/winter 2013-14 it is joined by two more high-street brands. Rihanna showed her debut collection for River Island last night, while Whistles will present a collection at an intimate salon show today, with fans of the brand watching live online.

Source: http://rss.feedsportal.com/c/33846/f/610141/p/1/s/c2daa8b/l/0L0Sscotsman0N0Clondon0Efashion0Eweek0Eold0Eguard0Eproves0Etalent0E10E27960A91/story01.htm

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রবিবার, ১৭ ফেব্রুয়ারি, ২০১৩

Q&A: Currency the latest threat to global economy

LONDON (AP) ? The world economy faces a new threat. Instead of a banking collapse or too much debt, fears are growing that countries are using their currencies as an economic weapon.

History suggests that's never a good thing.

If too many countries try to weaken their currencies for economic gain ? sparking a "currency war" ? that could stifle business confidence and investment, sow turmoil in financial markets and derail a fragile global economy.

Following their meeting in Moscow this weekend, financial representatives from the world's leading 20 industrial and developing countries warned that "excess volatility of financial flows and disorderly movements in exchange rates have adverse implications for economic and financial stability."

Why is everyone talking about currencies?

? Since the start of the financial crisis, central banks around the world have been trying to stimulate their economies by keeping interest rates extremely low. The goal is to encourage consumers and businesses to borrow and spend more. One way central banks drive down rates is to use their power to print money to buy up large quantities of bonds. But by boosting the amount of currency in circulation, there is a side effect: it can drive down the value of that currency relative to others.

As a country's currency falls, its exports become cheaper, while those of its neighbors become relatively more expensive.

Japan, the world's third-largest economy, is currently under the harshest spotlight. To get its economy motoring again after a two-decade bout of stagnation, the government has said it would like to see inflation move higher. Markets have interpreted this as a signal that Japan's central bank is prepared to take actions that would result in driving down the yen, to boost exports and also put upward pressure on prices. Earlier this week, the yen fell to a 21-month low against the dollar and a near three-year trough against the euro.

So is Japan actively trying to weaken the yen?

? Yes and no. Though it's not directly intervening in the foreign exchange markets by selling yen and buying other currencies, strong comments from the new Japanese government have convinced markets that the Bank of Japan will create more money. Japan's Finance Minister Taro Aso insists the government isn't focused on exchange rates, but he has noted that the weakening yen has "brought huge benefits to the export sector" and that the world "has been awed" by the recent surge in share prices.

Why is that bad?

? A falling yen will help exporters, such as Sony and Toyota, and boost Japan's economy. And it will it tend to push prices - and ultimately wages ? higher. But if other countries respond to the falling yen by devaluing their currencies ? to maintain the competitiveness of their own exports ? Japan will be back to square one and the world economy could suffer.

Sharp fluctuations in the value of currencies can hurt business confidence and investment. Prices for imported raw materials and components would be volatile, profits will be hard to come by as prices fluctuate wildly and the value of any investment a company makes in another country could quickly be wiped out.

Who's been feeling the effect of Japan's actions so far?

? The euro, the currency used by the 17-strong group of European Union countries, has seen the biggest move on the foreign exchange markets. As the region moved on from its crippling debt crisis last summer, the euro has slowly gained in value. But since the change of government in Japan, its value against leading currencies such as the yen and U.S. dollar has shot up ? last December it was worth 113.19 yen and $1.29 and now it's at 124.93 yen and $1.33.

A rise in the value of the euro will do little to help the eurozone's businesses ? and will hardly help getting it growing again. Figures Thursday showed that the economic output of the region shrank at an annualized rate of around 2.5 percent in the last quarter of 2012.

What's been the reaction from other major economies?

? Politicians have voiced concerns about the euro's rise versus other major currencies ? most notably French President Francois Hollande, who indicated he was open to calls for a more managed exchange rate. European Central Bank President Mario Draghi said last week that the bank will monitor the economic impact of the euro's rising value. Several analysts took that to mean the ECB could cut interest rates to bolster growth, which in theory could weaken the euro ? an indirect tit-for-tat response to the yen's fall, some say.

Earlier this week, the volatility in the currency markets prompted the Group of Seven leading industrial nations, which includes the U.S, Germany as well as Japan, to warn about the effects of volatile movements in exchange rates.

Might other countries try to manipulate their currencies in response to Japan?

? There is no sign of that ? so far. Speaking in Moscow Saturday, International Monetary Fund Director Christine Lagarde dismissed the possibility of an international currency conflict, saying that she was witnessing "currency worries, not currency wars."

But a country fixing the value of its currency is not without precedent.

In Sept. 2011, Switzerland took action to arrest the rise of its currency, the Swiss franc. The rise was triggered by the debt crisis in the eurozone ? investors were looking for somewhere safe to park their cash and the Swiss franc has traditionally fulfilled that role. The Swiss intervention was viewed as an attempt to protect the country's exporters.

U.S. politicians have for years accused China of keeping its currency, the renminbi, artificially weak in order to industrialize fast. And many countries believe the U.S. long ago abandoned the "strong dollar" policy in a dash for growth.

How bad could a currency war get?

? Since World War II, one of the key objectives of international economic policymaking has been to avoid a repeat of the 1930s, when countries around the world engaged in a tit-for-tat battle with their exchange rates. That decimated global trade, accentuating the depression and providing another catalyst to war.

Assuming the world doesn't descend into a similar abyss, a currency war can still harm the global economy. For example, central banks, particularly in the developing world, may resort to controlling the amount of capital that can be moved out of a country to affect exchange rates.

"Increasing impediments to the free flow of capital might be thought to lower the potential growth of the world economy," said Stephen Lewis, chief economist at Monument Securities.

Can the world's leaders and central bankers calm the situation?

? As many analysts had expected, this weekend's G-20 meeting in Moscow finished on Saturday with a warning on the dangers of competitive devaluations and a pledge that it will "not target our exchange rates for competitive purposes, will resist all forms of protectionism and keep our markets open."

The G20 communique ? and the G7 statement earlier this week ? failed to single out one country's actions for criticism.

Sung Won Sohn, an economics professor at the Martin Smith School of Business at California State University, said that should come as no surprise.

"Many countries including China, Japan and the United States all have issues related to exchange rates," he said. "People in glass houses should not throw stones."

Source: http://news.yahoo.com/q-currency-latest-threat-global-economy-114752248--finance.html

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